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Hirotaka Onoe Selected Research

Esters

11/2022Synthesis and Preclinical Evaluation of 18F-Labeled Ketoprofen Methyl Esters for Cyclooxygenase-1 Imaging in Neuroinflammation.
1/2016Exploratory human PET study of the effectiveness of (11)C-ketoprofen methyl ester, a potential biomarker of neuroinflammatory processes in Alzheimer's disease.
7/2011In vivo expression of cyclooxygenase-1 in activated microglia and macrophages during neuroinflammation visualized by PET with 11C-ketoprofen methyl ester.
4/2010General method for the (11)C-labeling of 2-arylpropionic acids and their esters: construction of a PET tracer library for a study of biological events involved in COXs expression.

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Hirotaka Onoe Research Topics

Disease

8Neoplasms (Cancer)
01/2023 - 04/2012
8Parkinson Disease (Parkinson's Disease)
10/2022 - 11/2011
6Neuroinflammatory Diseases
11/2022 - 04/2010
5Alzheimer Disease (Alzheimer's Disease)
01/2017 - 01/2012
4Inflammation (Inflammations)
01/2023 - 04/2010
4Neurodegenerative Diseases (Neurodegenerative Disease)
11/2022 - 07/2011
4Glaucoma
01/2013 - 01/2009
3Pain (Aches)
06/2013 - 11/2009
3Mental Disorders (Mental Disorder)
02/2013 - 01/2012
3Fatigue
02/2007 - 11/2002
2Atrophy
10/2022 - 03/2011
2Ischemia
09/2015 - 10/2013
2Brain Ischemia (Cerebral Ischemia)
09/2012 - 11/2006
2Chronic Fatigue Syndrome (Myalgic Encephalomyelitis)
01/2012 - 12/2004
1Teratoma (Teratoid Tumor)
03/2024
1Brain Neoplasms (Brain Tumor)
01/2023
1Lewy Body Disease (Lewy Body Dementia)
10/2022
1Dementia (Dementias)
10/2022
1Epilepsy (Aura)
12/2019
1Glut1 Deficiency Syndrome
12/2019
1Retinal Degeneration
01/2019
1Burns
01/2017
1Tauopathies
01/2017
1Autism Spectrum Disorder
01/2017
1Autistic Disorder (Autism)
01/2017
1Uremia
06/2016
1Amyloid Plaque
02/2016
1Cognitive Dysfunction
01/2016
1Atherosclerotic Plaque (Atheroma)
01/2016
1Glioma (Gliomas)
12/2015
1Adenocarcinoma
12/2015
1Brain Diseases (Brain Disorder)
08/2014
1Brain Injuries (Brain Injury)
10/2013
1Hyperalgesia
06/2013
1Treatment-Resistant Depressive Disorder
02/2013
1Memory Disorders (Memory Loss)
02/2013

Drug/Important Bio-Agent (IBA)

5ketoprofen methyl esterIBA
01/2023 - 07/2011
5Biomarkers (Surrogate Marker)IBA
01/2016 - 02/2007
4EstersIBA
11/2022 - 04/2010
4LipopolysaccharidesIBA
11/2022 - 04/2010
4Proteins (Proteins, Gene)FDA Link
12/2019 - 01/2012
4EnzymesIBA
02/2016 - 02/2007
3Cyclooxygenase 1IBA
11/2022 - 07/2011
3AcidsIBA
11/2022 - 04/2010
3Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
02/2016 - 04/2010
3ProstaglandinsIBA
02/2016 - 04/2010
3LigandsIBA
01/2012 - 11/2006
2Leucine (L-Leucine)FDA Link
01/2023 - 11/2021
2Glucose (Dextrose)FDA LinkGeneric
10/2022 - 12/2019
2Indicators and Reagents (Reagents)IBA
01/2021 - 01/2012
2Cholinergic Agents (Cholinergics)IBA
01/2017 - 01/2012
2Serotonin (5 Hydroxytryptamine)IBA
01/2017 - 12/2004
2Oxygen (Dioxygen)IBA
09/2015 - 11/2006
2Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
08/2014 - 04/2010
2MGS 0028IBA
02/2013 - 01/2012
2Glutamic Acid (Glutamate)FDA Link
02/2013 - 01/2012
21- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
10/2012 - 08/2012
2GABA-A Receptors (GABA(A) Receptor)IBA
01/2012 - 11/2009
2Neurotransmitter Agents (Neurotransmitter)IBA
12/2004 - 11/2002
1Amino AcidsFDA Link
01/2023
1Amino Acid Transport Systems (Amino Acid Transporter)IBA
01/2023
1Methionine (L-Methionine)FDA Link
01/2023
1Ac- Nal(1)- Cpa(2)- Pal(3,6)- Arg(5)- Ala(10)- LHRHIBA
01/2023
1Ketoprofen (Orudis)FDA LinkGeneric
11/2022
1SynucleinsIBA
10/2022
1leucine methyl esterIBA
11/2021
1IntegrinsIBA
01/2021
1arginyl-glycyl-aspartic acidIBA
01/2021
1Doxorubicin (Adriamycin)FDA LinkGeneric
01/2021
1Facilitative Glucose Transport Proteins (Glucose Transporter)IBA
12/2019
1AcetylcholinesteraseIBA
01/2017
1Advanced Glycation End ProductsIBA
06/2016
1Polysaccharides (Glycans)IBA
05/2016
1AlbuminsIBA
05/2016
1AsparagineIBA
05/2016
1Deoxyglucose (2 Deoxy D glucose)IBA
01/2016
12- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA
01/2016
1ThymidineIBA
12/2015
11- methyl- 5- (3- azido- 2,3- dideoxy- beta- pentofuranosyl)uracilIBA
12/2015
1Stavudine (Zerit)FDA LinkGeneric
12/2015
1NucleosidesIBA
12/2015
1rofecoxib (Vioxx)FDA Link
10/2013
1Celecoxib (Celebrex)FDA Link
10/2013
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
10/2013
1Kainic Acid (Kainate)IBA
06/2013
1acromelic acid AIBA
06/2013
1UBP296IBA
06/2013
1(2S,3R,4R)- 3- carboxymethyl- 4- (phenylthio)pyrrolidine- 2- carboxylic acidIBA
06/2013
1Dihydrotachysterol (AT 10)IBA
06/2013
1PoisonsIBA
06/2013
1alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA
06/2013
1Peptides (Polypeptides)IBA
05/2013
1Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA
02/2013
1CorticosteroneIBA
02/2013

Therapy/Procedure

8Therapeutics
01/2021 - 07/2011
4Lasers (Laser)
01/2017 - 03/2011
3Transplantation
03/2024 - 01/2013
3Light Coagulation
01/2017 - 03/2011
1Intravenous Injections
11/2021
1Cell Transplantation
04/2016